Curriculum Vitae

William Michael Carson, PhD

• Address:
  University of Alabama at Birmingham
  Center for Biophysical Sciences and Engineering
  1025 18th Street South
  Birmingham, AL 35294-4400
  

• Electronic:
  E-mail: carson@uab.edu
  Homepage: www.cbse.uab.edu/carson
  Office: (205)-934-7277; Fax: 975-0538
  

Professional Experience and Education:

• Adjunct Professor (2007) Department of Chemistry, Birmingham Southern College
• Research Associate Professor (2001-2006) Department of Biomedical Engineering, University of Alabama at Birmingham
• Associate Scientist (1998-2006) Comprehensive Cancer Center, University of Alabama at Birmingham
• Consultant (1988-1999) BioCryst Pharmaceuticals, Birmingham, Alabama
• Adjunct Assistant Professor (1986-present) Department of Computer and Information Sciences, University of Alabama at Birmingham
• Senior Research Associate (1984-1986) Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama
• Research Associate (1982-1984) Computational Chemistry and Molecular Graphics, University of North Carolina, Chapel Hill, North Carolina
• Postdoctoral Fellow (1980-1981) Crystallography, Max-Planck Institute for Biochemistry, Munich, Germany
• PhD (1980) Chemistry, University of Texas, Austin, Texas
• BS (1973) Chemistry, University of Arkansas, Fayetteville, Arkansas

Selected publications:

• M Carson (2007) Electron density fitting and structure validation. Macromolecular Crystallography: conventional and high-throughput methods, MR Sanderson and JV Skelly, eds, Oxford University Press.
• M Carson, DH Johnson, H McDonald, C Brouillette and LJ DeLucas (2007) His-tag impact on structure. Acta Cryst D63:295-301.
• DH Johnson, J Tsao, M Luo and M Carson (2006) SGCEdb: a flexible database and web interface integrating experimental results and analysis for structural genomics focusing on Caenorhabditis elegans. Nucl. Acids Res. 34:D471-D474.
• N Schormann, B Pal, O Senkovich, M Carson, A Howard, C Smith, L DeLucas and D Chattopadhyay (2005) Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor. J. Struct. Biol. 152:64-75.
• WB Arendall III, W Tempel, JS Richardson, W Zhou, S Wang, IW Davis, ZJ Lu, JP Rose, WM Carson, M Luo, DC Richardson and BC Wang (2005) A test of enhancing model accuracy in high-throughput crystallography. J. Struct. Func. Genomics 6:1-11.
• CH Luan, S Qiu, JB Finley, M Carson, RJ Gray, W Huang, D Johnson, J Tsao, J Reboul, P Vaglio, DE Hill, M Vidal, LJ DeLucas and M Luo (2004) High-Throughput Expression of C. elegans Proteins. Genome Research 14:2102-2110.
• S Lu, J Symersky, S Li, M Carson, L Chen, E Meehan and M Luo (2004) Structural Genomics of Caenorhabditis elegans: Crystal Structure of the Tropomodulin C-Terminal Domain. Proteins 53:944-946.
• ZW Yang, SW Tendian, WM Carson, WJ Brouillette, LJ DeLucas and CG Brouillette (2004) DMSO at 2.5% (v/v) Alters the Structural Cooperativity and Unfolding Mechanism of Dimeric Bacterial NAD Synthetase. Protein Science 13:830-841.
• J Symersky, S Li, M Carson, D Luo, CH Luan and M Luo (2003) Structural Genomics of Caenorhabditis elegans: Strucure of Dihydropteridine Reductase. Proteins 53:944-946.
• J Symersky, G Lin, S Li, M Carson, N Schormann and M Luo (2003) Structural Genomics of Caenorhabditis elegans: Crystal Strucure of Calmodulin. Proteins 53:947-949.
• CCS Deivanayagam, S Perkins, T Bice, M Carson, KR Rajashankar, EJ Walsh, TJ Foster, M Hook and SVL Narayana (2003) Crystal Structure of the Fibrinogen-Binding Region of Clumping Factor B, a Staphylococcus aureus Adhesin. JBC (accepted).
• J Symersky, S Li, M Carson, M Luo (2003) Structural genomics of Caenorhabditis elegans: Triosephosphate Isomerase. Proteins 51:484-486.
• S Li, J Finley, ZJ Liu, SH Qiu, H Chen, CH Luan, M Carson, J Tsao, D Johnson, G Lin, J Zhao, W Thomas, LA Nagy, B Sha, LJ DeLucas, BC Wang and M Luo (2002) Crystal Structure of the Cytoskeleton-associated Protein Glycine-rich (CAP-Gly) Domain. J.Biol.Chem. 277:48596-48601.
• CCS Deivanayagam, ER Wann, W Chen, M Carson, CS Ramarao, KR Rajashankar, M Hook and SVL Narayana (2002) Crystal Structure of Clumping Factor A: a Fibrinogen-Binding MSCRAMM of Staphylococcus aureus. EMBO Journal 21:6660-6672.
• MS Kumar, M Carson, MM Hussain and HMK Murthy (2002) Structures of Apolipoprotein A-II and a Lipid-Surrogate Complex Provide Insights into Apolipoprotein-Lipid Interactions. Biochemistry 41:11681-11691.
• CD Smith, M Carson, AM Friedman, MM Skinner, L DeLucas, L Chantalat, L Weiss, T Shirasawa and D Chattopadhyay (2002) Crystal Structure of Human L-Isoaspartyl-O-Methyltransferase with S-Adenosyl Homocysteine at 1.5A Resolution and Modeling of an Isoaspartyl Containing Peptide at the Active Site. Protein Science 11:625-635.
• R Recacha, M Carson, MJ Costanzo, LJ DeLucas and D Chattopadhyay (2000) Structure of the RWJ-51438-Human alpha-Thrombin Complex at 1.7A. Acta Cryst D55:1785-1791.
• D Chattopadhyay, G Langsley, M Carson, R Recacha, L DeLucas and CD Smith (2000) Structure of the nucleotide-binding domain of Plasmodium falciparum Rab6 in the GDP-bound form. Acta Cryst D56:937-944.
• H Jing, Y Xu, M Carson, D Moore, KJ Macon, JE Volanakis and SVL Narayana (2000) New Structural Motifs on the Chymotrypsin Fold and Their Potential Roles in Complement Factor B. EMBO Journal 19:164-173.
• CCS Deivanayagam, M Carson, A Thotakura, SVL Narayana and RS Chodavarapu (2000) The Crystal Structure of FKBP12.6 in Complex with Rapamycin. Acta Cryst D56:266-271.
• CCS Deivanayagam, RL Rich, M Carson, RT Owens, S Danthuluri, T Bice, M Hook and SVL Narayana (2000) Novel Fold and Assembly of the Repetitive B Region of the Staphylococcus aureus Collagen-binding Surface Protein. Structure 8:67-78.
• R Recacha, M Carson, MJ Costanzo, B Maryanoff, LJ DeLucas and D Chattopadhyay (1999) Structure of the RWJ-51084-Bovine Pancreatic beta-Trypsin Complex at 1.8A. Acta Cryst D55: 1785-1791.
• RL Rich, CCS Deivanayagam, RT Owens, M Carson, A Hook, D Moore, VWC Yang, SVL Narayana and M Hook (1999) Trench-shaped Binding Sites Promote Multiple Classes of Interactions between Collagen and the Adherence Receptors, alpha-1 beta-1 Integrin and S.aureus Cna MSCRAMM. J.Biol.Chem 274:24906-24913.
• SVL Narayana, JS Elce, D Chattopadhyay, G-D Lin, M Carson, H Blanchard, P Grochulski and M Cygler (1999) Structure and Assembly of the Calcium-Binding Domains of Calpain. CALPAIN: Pharmacology and Toxicology of Calcium-Dependent Protease, KKW Wang and P-W Yuen, eds, Taylor and Francis, Philadelphia, USA.
• J Symersky, JM Patti, M Carson, M Teale, D Moore, L Jin, LJ DeLucas, M. Hook and SVL Narayana (1997) The Collagen-binding Domain of Staphylococcus aureus Adhesin. Nature Struc. Biol. 4:833-838.
• G Lin, D Chattopadhyay, M Maki, KKW Wang, M Carson, L Jin, P Yuen, E Takano, M Hatanaka, LJ DeLucas and SVL Narayana (1997) Crystal Structure of Calcium Bound Domain VI of Calpain at 1.9A Resolution and its Role in Enzyme Assembly, Regulation, and Inhibitor Binding. Nature Struc. Biol. 4:539-547.
• A Agrawal, SJ Lee, M Carson, SVL Narayana, TJ Greenhough and JE Volanakis (1997) Site-directed Mutagenesis of the Phosphocholine-binding Site of Human C-Reactive Protein: Role of Thr76 and Trp67. J. Immunol. 158:345-350.
• M Carson (1997) Ribbons. Methods in Enzymology 277:493-505: Macromolecular Crystallography, RM Sweet and CW Carter, eds, Academic Press.
• YS Babu, SE Ealick, WC Guida, MD Erion, JA Montgomery, JA Secrist, M Carson, SVL Narayana, WJ Cook and CE Bugg (1997) Design of PNP Inhibitors. Structure Based Drug Design Ch.5 pp.151-169, P Veerapandian, ed, Marcel & Decker.
• M Carson (1996) Wavelets and Molecular Structure J. Computer-Aided Molecular Design 10:273-283.
• M Carson (1995) Wavelets and Protein Structure. Chem.Design Automation News 10:31.
• M Carson, Z Yang, YS Babu and JA Montgomery (1995) Calculation of Relative Binding Affinities of Purine Nucleoside Phosphorylase Inhibitors. Acta Cryst. D51:536-540.
• M Carson (1995) In: SIGGRAPH 94 Application Slide Set. Computer Graphics 29:38-42. In: 1994 Molecular Graphics Art Show and Video Show. J. Mol. Graphics 13:223-234.
• M Carson, TW Buckner, Z Yang, SVL Narayana and CE Bugg (1994) Error Detection in Crystallographic Models. Acta Cryst. D50:900-909.
• M Carson, CE Bugg, LJ DeLucas and SVL Narayana (1994) Structure of a Novel Serine Protease Compared to Homology Models. Acta Cryst. D50:889-899.
• O El-Kabbani, NC Green, G Lin, M Carson, SVL Narayana, KM Moore, RG Flynn and LJ DeLucas (1994) Structures of Human and Porcine Aldehyde Reductase: An Enzyme Implicated in Diabetic Complications. Acta Cryst. D50:859-686.
• M Carson and Z Yang (1994) DNurbs: DNA modeled with NURBS. J.Mol.Graphics 12:178-184.
• M Carson (1994) Ribbons++. J.Mol.Graphics 12:67.
• MM Long, LJ DeLucas, C Smith, M Carson, K Moore, MD Harrington, DJ Pillion, SP Bishop, WM Rosenblum, RJ Naumann, A Chait, J Prahl and CE Bugg (1994) Protein Crystal Growth in Microgravity: Temperature Induced Large Scale Crystallization of Insulin. Microgravity Sciences and Technology 7:196-202.
• LJ DeLucas, MM Long, KM Moore, WM Rosenblum, TL Bray, C Smith, M Carson, SVL Narayana, D Carter, AD Clark Jr, RG Nanni, J Ding, A Jacobo-Molina, G Kamer, SH Hughes, E Arnold, HM Einspahr, LL Clancy, GSJ Rao, PF Cook, BG Harris, SH Munson, BC Finzel, A McPherson, PC Weber, FA Lewandowski, TL Nagabhushan, PP Trotta, P Reichert, MA Navia, KP Wilson, JA Thomson, RN Richards, KD Bowersox, CJ Meade, ES Baker, SP Bishop, BJ Dunbar, E Trinh, J Prahl, A Sacco Jr and CE Bugg (1994) Recent Results and New Hardware Developments for Protein Crystal Growth in Microgravity. J.Crystal Growth 135:183-195.
• SVL Narayana, M Carson, O El-Kabbani, JM Kilpatrick, D Moore, X Chen, CE Bugg, JE Volanakis and LJ DeLucas (1994) Structure of Human Factor D, a Complement System Protein at 2.0A Resolution. J.Mol.Biol. 235:695-708.
• CE Bugg, WM Carson and JA Montgomery (1993) Drugs by Design. Scientific American 269:92-98.
• P Bossart-Whitaker, M Carson, YS Babu, CD Smith, WG Laver and GM Air (1993) Three-Dimensional Structure of Influenza A N9 Neuraminidase and its Complex with the Inhibitor 2-deoxy 2,3-dehydro-N-acetyl Neuraminic Acid. J.Mol.Biol. 232:1069-1083.
• JS Beckman, M Carson, CD Smith and WH Koppenol (1993) ALS, SOD and peroxynitrite. Nature 364:584.
• JG Dohlman, A Lupas and M Carson (1993) Long charge-rich alpha-helices in systemic autoantigens. Biochem.Biophys.Res.Comm. 195:686-696.
• CD Smith, M Carson, M van der Woerd, J Chen, H Ischiropolous and JS Beckman (1992) Crystal Structure of the Reaction Product of Peroxynitrite with Bovine Cu,Zn Superoxide Dismutase. Arch.Biochem. Biophys. 299:350-355.
• B Zhao, M Carson, SE Ealick and CE Bugg (1992) Structure of Scorpion Toxin Variant-3 at 1.2A Resolution. J.Mol.Biol. 227:239-252.
• WJ Cook, LC Jeffrey, M Carson, Z Chen and CM Pickart (1992) Structure of a Diubiquitin Conjugate and a Model for Interaction with Ubiquitin-conjugating Enzyme (E2). J.Biol.Chem. 12:11-13.
• M Carson (1992) OMITMAP for UNIX. J.Appl.Cryst. 25:327-328.
• M Carson and CE Bugg (1992) Analysis of the Protein Backbone. IEEE Comp.Graphics 12:11-13.
• SE Ealick, WJ Cook, S Vijay-Kumar, M Carson, TL Nagabhushan, PP Trotta and CE Bugg (1991) Three-Dimensional Structure of Recombinant Human Interferon-gamma. Science 252:698-702.
• M Carson (1991) Ribbons 2.0. J.Appl.Cryst. 24:958-961.
• RS Rowland, M Carson and CE Bugg (1990) Applications of Crystallographic Databases in Molecular Design. in Design of Antiviral Agents, Academic Press.
• KN Pillai, BW Suter and M Carson (1988) Use of a Shared Memory Parallel Processor in the Restrained Least-Squares Procedure of Hendrickson and Konnert. J.Appl.Cryst. 21:512-515.
• M Carson and CE Bugg (1988) Protein Crystal Graphics. Abstract G2, Proceedings of the Annual Meeting of the American Crystallographic Association.
• M Carson (1987) Ribbon Models of Macromolecules. J.Mol.Graphics 5:103-106.
• M Carson and CE Bugg (1986) Algorithm for Ribbon Models of Proteins. J.Mol.Graphics 4:121-122.
• A Anderson, M Carson and J Hermans (1986) Molecular Dynamics Simulation Study of Polypeptide Conformational Equilibrium. Ann. N.Y. Acad. Sci. 482:51-59.
• M Carson and J Hermans (1984) The Molecular Dynamics Workshop Laboratory and Spruce: A Graphics Display Program for Molecular Dynamics Simulations. Molecular Dynamics and Protein Structure edited by J.Hermans and W.van Gunsteren, pp 165-166 and 119. Polycrystal Book Service.
• M Rocco, M Carson, R Hantgan, J McDonagh and J Hermans (1983) Dependence of the Shape of the Plasma Fibronectin Molecule on Solvent Composition: Ionic Strength and Glycerol Content. J. Biol. Chem. 258:14545-14549.

Memberships:

• American Crystallographic Association
• Molecular Graphics and Modeling Society
• Association for Computing Machinery
• IEEE Computer Society