Curriculum Vitae
William Michael Carson, PhD
- Address:
University of Alabama at Birmingham
Center for Biophysical Sciences and Engineering
1025 18th Street South
Birmingham, AL 35294-4400
- Electronic:
E-mail: carson@uab.edu
Homepage: www.cbse.uab.edu/carson
Office: (205)-934-7277; Fax: 975-0538
Professional Experience and Education:
- Adjunct Professor (2007) Department of Chemistry, Birmingham Southern College
- Research Associate Professor (2001-2006) Department of Biomedical
Engineering, University of Alabama at Birmingham
- Associate Scientist (1998-2006) Comprehensive Cancer Center, University
of Alabama at Birmingham
- Consultant (1988-1999) BioCryst Pharmaceuticals, Birmingham, Alabama
- Adjunct Assistant Professor (1986-present) Department of Computer and Information
Sciences, University of Alabama at Birmingham
- Senior Research Associate (1984-1986) Comprehensive Cancer Center, University
of Alabama at Birmingham, Birmingham, Alabama
- Research Associate (1982-1984) Computational Chemistry and Molecular Graphics,
University of North Carolina, Chapel Hill, North Carolina
- Postdoctoral Fellow (1980-1981) Crystallography, Max-Planck Institute for
Biochemistry, Munich, Germany
- PhD (1980) Chemistry, University of Texas, Austin, Texas
- BS (1973) Chemistry, University of Arkansas, Fayetteville, Arkansas
Selected publications:
- M Carson (2007)
Electron density fitting and structure validation.
Macromolecular Crystallography: conventional and high-throughput methods,
MR Sanderson and JV Skelly, eds, Oxford University Press.
- M Carson, DH Johnson, H McDonald, C Brouillette and LJ DeLucas (2007)
His-tag impact on structure.
Acta Cryst D63:295-301.
- DH Johnson, J Tsao, M Luo and M Carson (2006)
SGCEdb: a flexible database and web interface integrating experimental results
and analysis for structural genomics focusing on Caenorhabditis elegans.
Nucl. Acids Res. 34:D471-D474.
- N Schormann, B Pal, O Senkovich, M Carson, A Howard,
C Smith, L DeLucas and D Chattopadhyay (2005)
Crystal structure of Trypanosoma cruzi pteridine reductase 2
in complex with a substrate and an inhibitor.
J. Struct. Biol. 152:64-75.
- WB Arendall III, W Tempel, JS Richardson, W Zhou, S Wang, IW Davis,
ZJ Lu, JP Rose, WM Carson, M Luo, DC Richardson and BC Wang (2005)
A test of enhancing model accuracy in high-throughput crystallography.
J. Struct. Func. Genomics 6:1-11.
- CH Luan, S Qiu, JB Finley, M Carson, RJ Gray, W Huang, D Johnson, J Tsao,
J Reboul, P Vaglio, DE Hill, M Vidal, LJ DeLucas and M Luo (2004)
High-Throughput Expression of C. elegans Proteins.
Genome Research 14:2102-2110.
- S Lu, J Symersky, S Li, M Carson, L Chen, E Meehan and M Luo (2004)
Structural Genomics of Caenorhabditis elegans:
Crystal Structure of the Tropomodulin C-Terminal Domain.
Proteins 53:944-946.
- ZW Yang, SW Tendian, WM Carson, WJ Brouillette,
LJ DeLucas and CG Brouillette (2004)
DMSO at 2.5% (v/v) Alters the Structural Cooperativity and
Unfolding Mechanism of Dimeric Bacterial NAD Synthetase.
Protein Science 13:830-841.
- J Symersky, S Li, M Carson, D Luo, CH Luan and M Luo (2003)
Structural Genomics of Caenorhabditis elegans:
Strucure of Dihydropteridine Reductase.
Proteins 53:944-946.
- J Symersky, G Lin, S Li, M Carson, N Schormann and M Luo (2003)
Structural Genomics of Caenorhabditis elegans:
Crystal Strucure of Calmodulin.
Proteins 53:947-949.
- CCS Deivanayagam, S Perkins, T Bice, M Carson, KR Rajashankar, EJ Walsh,
TJ Foster, M Hook and SVL Narayana (2003)
Crystal Structure of the Fibrinogen-Binding Region of Clumping Factor B,
a Staphylococcus aureus Adhesin.
JBC (accepted).
- J Symersky, S Li, M Carson, M Luo (2003)
Structural genomics of Caenorhabditis elegans: Triosephosphate Isomerase.
Proteins 51:484-486.
- S Li, J Finley, ZJ Liu, SH Qiu, H Chen, CH Luan, M Carson,
J Tsao, D Johnson, G Lin, J Zhao, W Thomas, LA Nagy, B Sha,
LJ DeLucas, BC Wang and M Luo (2002)
Crystal Structure of the Cytoskeleton-associated Protein
Glycine-rich (CAP-Gly) Domain.
J.Biol.Chem. 277:48596-48601.
- CCS Deivanayagam, ER Wann, W Chen, M Carson, CS Ramarao, KR Rajashankar,
M Hook and SVL Narayana (2002) Crystal Structure of Clumping Factor A:
a Fibrinogen-Binding MSCRAMM of Staphylococcus aureus.
EMBO Journal 21:6660-6672.
- MS Kumar, M Carson, MM Hussain and HMK Murthy (2002)
Structures of Apolipoprotein A-II and a Lipid-Surrogate Complex
Provide Insights into Apolipoprotein-Lipid Interactions.
Biochemistry 41:11681-11691.
- CD Smith, M Carson, AM Friedman, MM Skinner, L DeLucas, L Chantalat,
L Weiss, T Shirasawa and D Chattopadhyay (2002)
Crystal Structure of Human L-Isoaspartyl-O-Methyltransferase
with S-Adenosyl Homocysteine at 1.5A Resolution and Modeling
of an Isoaspartyl Containing Peptide at the Active Site.
Protein Science 11:625-635.
- R Recacha, M Carson, MJ Costanzo, LJ DeLucas and D Chattopadhyay (2000)
Structure of the RWJ-51438-Human alpha-Thrombin Complex at 1.7A.
Acta Cryst D55:1785-1791.
- D Chattopadhyay, G Langsley, M Carson, R Recacha, L DeLucas and CD Smith
(2000) Structure of the nucleotide-binding domain of Plasmodium falciparum
Rab6 in the GDP-bound form. Acta Cryst D56:937-944.
- H Jing, Y Xu, M Carson, D Moore, KJ Macon, JE Volanakis and SVL Narayana
(2000) New Structural Motifs on the Chymotrypsin Fold and Their Potential
Roles in Complement Factor B. EMBO Journal 19:164-173.
- CCS Deivanayagam, M Carson, A Thotakura, SVL Narayana and RS Chodavarapu
(2000) The Crystal Structure of FKBP12.6 in Complex with Rapamycin. Acta Cryst D56:266-271.
- CCS Deivanayagam, RL Rich, M Carson, RT Owens, S Danthuluri, T Bice, M Hook
and SVL Narayana (2000) Novel Fold and Assembly of the Repetitive B Region
of the Staphylococcus aureus Collagen-binding Surface Protein. Structure 8:67-78.
- R Recacha, M Carson, MJ Costanzo, B Maryanoff, LJ DeLucas and D Chattopadhyay
(1999) Structure of the RWJ-51084-Bovine Pancreatic beta-Trypsin Complex
at 1.8A. Acta Cryst D55: 1785-1791.
- RL Rich, CCS Deivanayagam, RT Owens, M Carson, A Hook, D Moore, VWC Yang,
SVL Narayana and M Hook (1999) Trench-shaped Binding Sites Promote Multiple
Classes of Interactions between Collagen and the Adherence Receptors, alpha-1
beta-1 Integrin and S.aureus Cna MSCRAMM. J.Biol.Chem 274:24906-24913.
- SVL Narayana, JS Elce, D Chattopadhyay, G-D Lin, M Carson, H Blanchard,
P Grochulski and M Cygler (1999) Structure and Assembly of the Calcium-Binding
Domains of Calpain. CALPAIN: Pharmacology and Toxicology of Calcium-Dependent
Protease, KKW Wang and P-W Yuen, eds, Taylor and Francis, Philadelphia,
USA.
- J Symersky, JM Patti, M Carson, M Teale, D Moore, L Jin, LJ DeLucas,
M. Hook and SVL Narayana (1997) The Collagen-binding Domain of Staphylococcus aureus Adhesin. Nature Struc. Biol. 4:833-838.
- G Lin, D Chattopadhyay, M Maki, KKW Wang, M Carson, L Jin, P Yuen, E Takano,
M Hatanaka, LJ DeLucas and SVL Narayana (1997) Crystal Structure of Calcium
Bound Domain VI of Calpain at 1.9A Resolution and its Role in Enzyme Assembly,
Regulation, and Inhibitor Binding. Nature Struc. Biol. 4:539-547.
- A Agrawal, SJ Lee, M Carson, SVL Narayana, TJ Greenhough and JE Volanakis
(1997) Site-directed Mutagenesis of the Phosphocholine-binding
Site of Human C-Reactive Protein: Role of Thr76 and Trp67. J. Immunol. 158:345-350.
- M Carson (1997) Ribbons. Methods in Enzymology 277:493-505: Macromolecular Crystallography, RM Sweet and CW Carter, eds,
Academic Press.
- YS Babu, SE Ealick, WC Guida, MD Erion, JA Montgomery, JA Secrist,
M Carson, SVL Narayana, WJ Cook and CE Bugg (1997) Design of PNP
Inhibitors. Structure Based Drug Design Ch.5 pp.151-169, P Veerapandian, ed, Marcel & Decker.
- M Carson (1996) Wavelets and Molecular Structure J. Computer-Aided Molecular Design 10:273-283.
- M Carson (1995) Wavelets and Protein Structure. Chem.Design Automation News 10:31.
- M Carson, Z Yang, YS Babu and JA Montgomery (1995) Calculation of
Relative Binding Affinities of Purine Nucleoside Phosphorylase Inhibitors. Acta Cryst. D51:536-540.
- M Carson (1995) In: SIGGRAPH 94 Application Slide Set. Computer Graphics 29:38-42. In: 1994 Molecular Graphics Art Show and Video Show. J. Mol. Graphics 13:223-234.
- M Carson, TW Buckner, Z Yang, SVL Narayana and CE Bugg (1994) Error
Detection in Crystallographic Models. Acta Cryst. D50:900-909.
- M Carson, CE Bugg, LJ DeLucas and SVL Narayana (1994) Structure
of a Novel Serine Protease Compared to Homology Models. Acta Cryst. D50:889-899.
- O El-Kabbani, NC Green, G Lin, M Carson, SVL Narayana, KM Moore,
RG Flynn and LJ DeLucas (1994) Structures of Human and Porcine Aldehyde
Reductase: An Enzyme Implicated in Diabetic Complications. Acta Cryst. D50:859-686.
- M Carson and Z Yang (1994) DNurbs: DNA modeled with NURBS. J.Mol.Graphics 12:178-184.
- M Carson (1994) Ribbons++. J.Mol.Graphics 12:67.
- MM Long, LJ DeLucas, C Smith, M Carson, K Moore, MD Harrington,
DJ Pillion, SP Bishop, WM Rosenblum, RJ Naumann, A Chait, J Prahl
and CE Bugg (1994) Protein Crystal Growth in Microgravity: Temperature
Induced Large Scale Crystallization of Insulin. Microgravity Sciences and Technology 7:196-202.
- LJ DeLucas, MM Long, KM Moore, WM Rosenblum, TL Bray, C Smith,
M Carson, SVL Narayana, D Carter, AD Clark Jr, RG Nanni, J Ding,
A Jacobo-Molina, G Kamer, SH Hughes, E Arnold, HM Einspahr, LL Clancy,
GSJ Rao, PF Cook, BG Harris, SH Munson, BC Finzel, A McPherson,
PC Weber, FA Lewandowski, TL Nagabhushan, PP Trotta,
P Reichert, MA Navia, KP Wilson, JA Thomson, RN Richards, KD Bowersox,
CJ Meade, ES Baker, SP Bishop, BJ Dunbar, E Trinh, J Prahl,
A Sacco Jr and CE Bugg (1994) Recent Results and New Hardware
Developments for Protein Crystal Growth in Microgravity. J.Crystal Growth 135:183-195.
- SVL Narayana, M Carson, O El-Kabbani, JM Kilpatrick, D Moore, X Chen,
CE Bugg, JE Volanakis and LJ DeLucas (1994) Structure of Human Factor D,
a Complement System Protein at 2.0A Resolution.
J.Mol.Biol. 235:695-708.
- CE Bugg, WM Carson and JA Montgomery (1993) Drugs by Design. Scientific American 269:92-98.
- P Bossart-Whitaker, M Carson, YS Babu, CD Smith, WG Laver and GM Air
(1993) Three-Dimensional Structure of Influenza A N9 Neuraminidase and its
Complex with the Inhibitor 2-deoxy 2,3-dehydro-N-acetyl Neuraminic Acid.
J.Mol.Biol. 232:1069-1083.
- JS Beckman, M Carson, CD Smith and WH Koppenol (1993) ALS, SOD and
peroxynitrite. Nature 364:584.
- JG Dohlman, A Lupas and M Carson (1993) Long charge-rich alpha-helices
in systemic autoantigens. Biochem.Biophys.Res.Comm. 195:686-696.
- CD Smith, M Carson, M van der Woerd, J Chen, H Ischiropolous and JS Beckman
(1992) Crystal Structure of the Reaction Product of Peroxynitrite
with Bovine Cu,Zn Superoxide Dismutase. Arch.Biochem. Biophys. 299:350-355.
- B Zhao, M Carson, SE Ealick and CE Bugg (1992) Structure of Scorpion
Toxin Variant-3 at 1.2A Resolution. J.Mol.Biol. 227:239-252.
- WJ Cook, LC Jeffrey, M Carson, Z Chen and CM Pickart (1992)
Structure of a Diubiquitin Conjugate and a Model
for Interaction with Ubiquitin-conjugating Enzyme (E2).
J.Biol.Chem. 12:11-13.
- M Carson (1992) OMITMAP for UNIX. J.Appl.Cryst. 25:327-328.
- M Carson and CE Bugg (1992) Analysis of the Protein Backbone. IEEE Comp.Graphics 12:11-13.
- SE Ealick, WJ Cook, S Vijay-Kumar, M Carson, TL Nagabhushan, PP
Trotta and CE Bugg (1991) Three-Dimensional Structure of Recombinant Human
Interferon-gamma. Science 252:698-702.
- M Carson (1991) Ribbons 2.0. J.Appl.Cryst. 24:958-961.
- RS Rowland, M Carson and CE Bugg (1990) Applications of Crystallographic
Databases in Molecular Design. in Design of Antiviral Agents, Academic Press.
- KN Pillai, BW Suter and M Carson (1988) Use of a Shared Memory Parallel
Processor in the Restrained Least-Squares Procedure of Hendrickson and Konnert. J.Appl.Cryst. 21:512-515.
- M Carson and CE Bugg (1988) Protein Crystal Graphics. Abstract G2, Proceedings
of the Annual Meeting of the American Crystallographic Association.
- M Carson (1987) Ribbon Models of Macromolecules. J.Mol.Graphics 5:103-106.
- M Carson and CE Bugg (1986) Algorithm for Ribbon Models of Proteins. J.Mol.Graphics 4:121-122.
- A Anderson, M Carson and J Hermans (1986) Molecular Dynamics Simulation
Study of Polypeptide Conformational Equilibrium. Ann. N.Y. Acad. Sci. 482:51-59.
- M Carson and J Hermans (1984) The Molecular Dynamics Workshop Laboratory
and Spruce: A Graphics Display Program for Molecular Dynamics Simulations.
Molecular Dynamics and Protein Structure edited by J.Hermans and W.van Gunsteren,
pp 165-166 and 119. Polycrystal Book Service.
- M Rocco, M Carson, R Hantgan, J McDonagh and J Hermans (1983) Dependence
of the Shape of the Plasma Fibronectin Molecule on Solvent Composition:
Ionic Strength and Glycerol Content. J. Biol. Chem. 258:14545-14549.
Memberships:
- American Crystallographic Association
- Molecular Graphics and Modeling Society
- Association for Computing Machinery
- IEEE Computer Society