My major contribution to this chapter was a study of amino acid surface preferences in globular proteins. This work was first presented at the 1988 ACA meeting. All is explained in the figures below:

Amino acid sidechain surface preferences

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The Aij value measures the preference of each type of amino acid sidechain to share surface area with any other type. A value of 1.0 is neutral; greater than one is a preference. The amino acids are sorted by their preference to water. Single letter codes are employed, and color-coded according to class. Additional codes are 'B' for backbones, 'O' for water, 'X' for any heteroatom, 'Z' for chain terminii (the N,CA,C,O atoms were considered 'B', glycine treated separately). 'Cs and Ch refer to disulphides and free sulphydryl forms.