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The CBSE has a history of expertise in structural biology research and the development of enabling technologies in the life science and aerospace industries. Encompassing both divisions of Life Sciences and Engineering the CBSE now has over 100 employees dedicated to both fields.
 Our history also includes the designation as a NASA as a Research Partnership Center aimed at fostering the participation of industry in the commercial development of space- related research. Our concentration in the area of protein structural information and the discovery and development of new drugs bridged the access for those interested in the effects of microgravity in scientific research. In 1990, the Engineering Division was established to develop innovative enabling technologies and support the scientific community through the design and operation of ground-based and microgravity specialty instrumentation and software development services.
Today, the CBSE Life Science Division is one of the most prolific generators of completely novel high-resolution protein structures and co-crystal structures to reveal the detailed molecular interactions in drug discovery research. Our internal programs in Drug Discovery are focused on understanding the structure and function of macromolecules as applied to new drug discovery via intelligent or structure-based, combinatorial design. These efforts have resulted over 500 publications, 20+ patents, multiple license arrangements, and the creation of several successful spin-off companies.
 Our internal research program spans a variety of pharmaceutical drug targets, enabling platform technologies and basic research in proteomics.
Pharmaceutical Drug Target Development:
- Cystic Fibrosis
- T-Cell Mediated Diseases
- Bone Loss Disorders
- Cardiovascular Syndromes
- Oncological Diseases
- Influenza
- Small Pox
- Anthrax
- Chagas Disease
- Dengue Virus
- Agricultural products
- And other chronic and infectious diseases
Enabling Technology Platforms – examples include:
- High Throughput Crystallization Instrumentation Design
- Automated Rotary Bioreactors
- Self Interaction Chromatography
- Electroporation
- Biosensors
- Thermal Carrier Units for Microgravity
- Protein Crystal Growth Hardware for Microgravity
Basic Research:
- GPCR’s
- Cytokines
- Kinases
- Toll Like Receptors
- Molecular Chaperones (HSP)
- Neuraminadse Inhibitors
- Retinoids
- Antimicrobial resistance
- Sodium channel ligands
- Protein-protein interactions
- Innovative protein expression and crystallization methods
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